Thursday, July 17, 2025

Laurabolin 25 mg/ml Solution for injection

 



Laurabolin 10ml

Laurabolin is a solution for injection containing the active ingredient nandrolone laurate, a derivative of testosterone for use in dogs and cats. It is classified as an anabolic steroid with significant anabolic (tissue-building) and anti-catabolic (tissue-preserving) effects. 

This product may only be prescribed by your local veterinary practitioner from whom advice should be sought. Laurabolin contains a clear oily solution for injection containing 25 mg Nandrolone Laurate per ml. Also contains 10.4% w/v Benzyl Alcohol as preservative.

 

For uses, dosage, contra-indications and warnings please consult product leaflet. Further information is available on request. Use medicines responsibly.

 

Active ingredients

Strength available: 25 mg nandrolone laurate per ml.

 

Target species

Cats, Dogs

 

Indications for use

Nandrolone is a testosterone derivative which can be used in the supportive management of chronic renal failure.

For the correction of metabolic disorders such as: retarded animals, malnutrition, sequelae of bacterial, viral or parasitic diseases, anemias, weaning, corticotherapies, animals subjected to physical exertion and geriatrics.

 

Legal Category
POM

 

Packaging Quantities
25 mg/ml: 10 ml vials.

 

Prednisolone injection

 



Horses are majestic animals that play vital roles in sports, recreation, and work across the globe. Like humans, horses can suffer from a variety of health issues, including inflammatory and allergic conditions. Managing these ailments effectively is crucial to ensuring the health, comfort, and performance of your equine companions.

One medication that has gained prominence in equine medicine is Prednisolone — a corticosteroid with potent anti-inflammatory and immunosuppressive properties. This article provides an in-depth exploration of Prednisolone for horses, including its uses, dosing guidelines, safety precautions, and its role in veterinary practice.


What Is Prednisolone?

Prednisolone is a synthetic corticosteroid that mimics the action of naturally occurring hormones produced by the adrenal glands. It exerts its effects by suppressing inflammatory responses and modulating immune system activity.

In veterinary medicine, prednisolone is used to treat a range of conditions, including:

  • Allergic reactions
  • Inflammatory diseases
  • Autoimmune disorders
  • Respiratory conditions
  • Certain skin diseases

Its efficacy in reducing inflammation and immune responses makes it a valuable tool in managing complex health issues in horses.


How Does Prednisolone Work in Horses?

Prednisolone works by penetrating cell membranes and binding to glucocorticoid receptors in the cytoplasm. This complex then moves to the cell nucleus, influencing gene expression to suppress the production of inflammatory mediators such as prostaglandins and leukotrienes.

The primary effects of prednisolone include:

  • Anti-inflammatory: Reduces swelling, redness, and pain associated with inflammation.
  • Immunosuppressive: Suppresses overactive immune responses, beneficial in autoimmune conditions.
  • Metabolic effects: Alters carbohydrate, protein, and fat metabolism, which can influence energy levels and weight.

In horses, these effects translate into relief from allergic reactions, control of autoimmune diseases, and management of various inflammatory conditions.


Common Uses of Prednisolone in Horses

1. Allergic Reactions and Respiratory Diseases

Horses often suffer from allergic airway diseases, such as heaves (equine asthma), which involve inflammation of the airways. Prednisolone can be prescribed to alleviate airway inflammation, improve breathing, and reduce coughing.

2. Autoimmune and Inflammatory Conditions

Autoimmune diseases like immune-mediated skin diseases and arthritis may benefit from corticosteroid therapy. Prednisolone helps suppress abnormal immune activity, reducing tissue damage.

3. Skin Conditions

Conditions such as dermatitis or allergic dermatitis may respond favorably to prednisolone, especially when inflammation is significant.

4. Post-Surgical and Post-Traumatic Inflammation

In cases where surgical or traumatic injury leads to excessive inflammation, prednisolone can be used to control swelling and promote healing.


Dosing and Administration Guidelines

Proper dosing of prednisolone in horses is critical to achieve therapeutic benefits while minimizing adverse effects. The dosage depends on the condition being treated, the severity of symptoms, and individual horse factors.

Typical Dosage Regimen

  • Initial Dose: 0.5 to 2 mg per kilogram of body weight per day, administered orally or via injection.
  • Maintenance Dose: Once symptoms improve, the dose may be gradually reduced to the lowest effective dose.
  • Duration: Treatment duration varies from a few days to several weeks, depending on the condition.

Forms of Prednisolone

  • Oral tablets or liquid: Convenient for long-term management.
  • Injectable forms: Used for rapid effect, especially in acute conditions.

Tapering and Discontinuation

Abrupt cessation can lead to adrenal insufficiency; therefore, gradual tapering of the dose is recommended.


Safety Precautions and Side Effects

While prednisolone is effective, it carries potential risks, especially if used improperly or over extended periods.

Common Side Effects

  • Increased thirst and urination
  • Increased appetite and weight gain
  • Gastrointestinal upset
  • Laminitis (especially in susceptible horses)
  • Suppressed immune function leading to increased infection risk
  • Behavioral changes

Long-Term Risks

Chronic use can lead to Cushing's syndrome, characterized by hair loss, a pot-bellied appearance, and other metabolic disturbances.

Contraindications

  • Horses with systemic infections (as corticosteroids suppress immune response)
  • Horses with existing laminitis
  • Pregnant mares (use with caution)

Monitoring During Therapy

Regular veterinary check-ups are essential. Monitoring includes:

  • Blood work to assess immune status and metabolic parameters
  • Observation for signs of laminitis
  • Evaluating the effectiveness and side effects

Best Practices for Using Prednisolone in Horses

  1. Consult a Veterinarian: Always seek veterinary guidance before administering prednisolone.
  2. Accurate Diagnosis: Ensure the underlying condition warrants corticosteroid therapy.
  3. Proper Dosing: Follow prescribed doses strictly; avoid self-medication.
  4. Monitoring: Keep track of clinical response and side effects.
  5. Gradual Tapering: Do not stop abruptly; taper doses to prevent adrenal insufficiency.
  6. Supporting Care: Provide supportive therapies such as antiulcer medication if needed.
  7. Avoid Long-Term Use: Use corticosteroids for the shortest effective duration.

Alternatives and Complementary Therapies

While prednisolone is effective, it should be used judiciously. Alternatives include:

  • Non-steroidal anti-inflammatory drugs (NSAIDs): Like phenylbutazone or flunixin.
  • Allergy management: Environmental modifications, antihistamines.
  • Physical therapy: To support recovery and reduce inflammation.
  • Immunotherapy: For specific allergic conditions.

Complementary therapies can help reduce reliance on corticosteroids and minimize side effects.


In competitive equine sports, corticosteroids are often regulated substances. Veterinarians and owners must:

  • Follow legal guidelines for drug withdrawal times.
  • Maintain accurate medication records.
  • Use approved formulations.

Failure to adhere to regulations can result in disqualification or sanctions.


Conclusion

Prednisolone for horses remains a valuable medication in the veterinary toolkit for managing a variety of inflammatory and autoimmune conditions. When used appropriately under veterinary supervision, it can significantly improve the quality of life for affected horses.

However, responsible use is essential to minimize adverse effects, especially with long-term therapy. Regular monitoring, dose adjustments, and considering alternative therapies are key components of safe corticosteroid management.

If you suspect your horse requires prednisolone or are considering its use, always consult an experienced equine veterinarian to develop a tailored treatment plan that prioritizes your horse's health and wellbeing.


Disclaimer: This article is for informational purposes only and does not substitute professional veterinary advice. Always consult your veterinarian before administering any medication to your horse.

Veterinary steroids Kazakhstan

 



Veterinary medicine plays a crucial role in ensuring the health, productivity, and well-being of animals across the globe. In Kazakhstan, a country with a rich tradition of livestock farming and animal husbandry, the use of veterinary pharmaceuticals, including steroids, has gained significant attention. Among these, veterinary steroids are particularly noteworthy due to their potent effects on animal growth, recovery, and disease management.

This comprehensive guide aims to shed light on veterinary steroids in Kazakhstan, exploring their types, applications, regulatory environment, industry trends, safety considerations, and future outlook. Whether you're a veterinarian, livestock farmer, researcher, or policy-maker, understanding the nuances of veterinary steroids is essential for promoting responsible use and safeguarding animal and public health.


What Are Veterinary Steroids?

Veterinary steroids are synthetic compounds that mimic or influence natural hormones in animals. They are used in veterinary medicine to:

  • Promote growth and weight gain in livestock
  • Accelerate recovery from injuries or illnesses
  • Manage inflammatory and allergic conditions
  • Improve reproductive performance

Types of Veterinary Steroids:

  1. Anabolic Steroids: Promote muscle growth and improve feed efficiency.
  2. Glucocorticoids: Reduce inflammation and suppress immune responses.
  3. Androgens: Influence reproductive functions and secondary sexual characteristics.
  4. Progestins and Estrogens: Used in reproductive management.

While these compounds can be beneficial when used appropriately, misuse or overuse can lead to adverse effects on animals, humans, and the environment. Cobra XT


The Role of Veterinary Steroids in Kazakhstan’s Animal Industry

Kazakhstan's economy relies heavily on agriculture, especially livestock farming, which includes cattle, sheep, horses, and camels. The demand for high-quality meat, dairy products, and wool necessitates efficient animal productivity.

Why Are Veterinary Steroids Used in Kazakhstan?

  • Enhance Growth Rates: To meet market demands and improve profitability.
  • Accelerate Recovery: For animals recovering from illness or injury.
  • Improve Reproductive Efficiency: In breeding programs.
  • Combat Diseases: Certain steroids have anti-inflammatory properties aiding in disease treatment.

The Impact on Kazakhstan's Livestock Sector

The strategic use of veterinary steroids has contributed to increased productivity, but it also raises concerns about:

  • Drug Residues: Potential contamination of meat and dairy products.
  • Antimicrobial Resistance: Overuse may contribute to resistant strains.
  • Animal Welfare: Risks of improper administration leading to health issues.

Regulatory Environment Surrounding Veterinary Steroids in Kazakhstan

Understanding the legal framework governing veterinary steroids is essential for responsible usage and compliance.

National Regulations

Kazakhstan's veterinary drug regulations are governed by the Committee of Veterinary Control and Supervision under the Ministry of Agriculture. The key points include:

  • Registration of Drugs: Only registered veterinary pharmaceuticals can be used.
  • Prescription Requirements: Steroids should be prescribed by licensed veterinarians.
  • Withdrawal Periods: Mandatory waiting times before animal products enter the food chain.
  • Record-Keeping: Farmers and veterinarians must maintain treatment records.

International Standards and Compliance

Kazakhstan aligns with international standards set by organizations such as the World Organisation for Animal Health (OIE) and the Codex Alimentarius. This includes:

  • Ensuring drug safety and efficacy.
  • Monitoring drug residues.
  • Implementing import/export controls for veterinary pharmaceuticals.

Challenges in Regulation

Despite regulations, challenges remain:

  • Illegal Import and Sale: Unregistered or counterfeit steroids may circulate.
  • Lack of Awareness: Farmers and some practitioners may lack knowledge about proper usage.
  • Monitoring Difficulties: Limited resources for comprehensive surveillance.

Types and Common Veterinary Steroids Used in Kazakhstan

1. Anabolic Steroids

Commonly used to promote growth in cattle and sheep, examples include:

2. Glucocorticoids

Used to treat inflammatory conditions:

3. Androgens and Progestins

Applied in reproductive management and breeding programs.

4. Emerging and Controversial Steroids

Some newer or less regulated compounds may be used illicitly, raising safety concerns.


Benefits of Veterinary Steroids in Kazakhstan’s Animal Industry

  • Enhanced Growth Rates: Reduced time to market for livestock.
  • Improved Feed Conversion: Getting more meat or milk per unit of feed.
  • Faster Recovery: Minimized downtime due to illness.
  • Reproductive Efficiency: Increased fertility rates.

Risks and Concerns Associated with Veterinary Steroids

While benefits exist, misuse carries significant risks:

1. Animal Health Risks

  • Hormonal imbalances
  • Liver and kidney damage
  • Behavioral changes
  • Reproductive issues

2. Food Safety Risks

  • Residues in meat, milk, and other products
  • Potential allergic reactions in humans
  • Development of antimicrobial resistance

3. Environmental Impact

  • Steroid residues may contaminate soil and water
  • Effects on wildlife and ecosystems
  • Illegal use or black-market trade
  • Lack of adherence to withdrawal periods

Responsible Use and Best Practices

To maximize benefits and minimize risks, stakeholders must adhere to:

  • Veterinary Oversight: Use steroids only under the supervision of qualified veterinarians.
  • Proper Dosing and Administration: Follow manufacturers’ guidelines.
  • Adherence to Withdrawal Periods: Ensure animal products are free of drug residues.
  • Record-Keeping: Maintain detailed treatment logs.
  • Monitoring and Surveillance: Regular testing for residues and adverse effects.
  • Education and Training: Ongoing training for farmers and veterinary staff.

The Future of Veterinary Steroid Use in Kazakhstan

  • Alternative Growth Promoters: Development of natural or non-hormonal alternatives.
  • Enhanced Regulations: Strengthening enforcement and monitoring.
  • Technological Advances: Use of biomonitoring and rapid testing methods.
  • International Collaboration: Working with global partners to align standards.

Challenges Ahead

  • Combating illegal trade and misuse
  • Ensuring equitable access to safe pharmaceuticals
  • Addressing public concerns over food safety
  • Promoting sustainable and ethical practices

Conclusion

Veterinary steroids in Kazakhstan occupy a complex space blending opportunities for enhancing animal productivity with the imperative of safeguarding animal welfare, human health, and the environment. Responsible use, strict regulation, ongoing education, and technological advancements are critical to harnessing their benefits while minimizing risks.

As Kazakhstan continues to develop its agricultural sector, stakeholders must prioritize transparency, compliance, and innovation to ensure that veterinary steroid use aligns with international standards and contributes positively to the country's economic and social development.


    Disclaimer: This content is for informational purposes only and does not substitute professional veterinary advice or legal consultation. Always consult qualified professionals for veterinary treatments and compliance issues.



    Buy Dexafort Injection Online Kazakhstan

     


    Are you searching for high-quality Dexafort 50ml injection for sale online in Kazakhstan? This comprehensive guide covers everything you need to know about Dexafort, its uses, benefits, purchasing tips, and how to ensure safe transactions. Read on to make informed decisions and find trusted sources for your veterinary and medical needs.


    What is Dexafort 50ml Injection?

    Dexafort injection is a potent corticosteroid medication widely used in veterinary medicine. It contains dexamethasone, a powerful ani-inflammatory and immunosuppressant agent. The 50ml injection form provides a convenient and effective way for veterinarians and qualified professionals to administer treatment to animals.

    Key Components and Composition

    • Active Ingredient: Dexamethasone (a synthetic glucocorticoid)
    • Concentration: Typically 2 mg/ml or as specified
    • Volume: 50ml per bottle

    Primary Uses of Dexafort

    • Managing inflammatory conditions
    • Treating allergic reactions
    • Suppressing immune responses post-surgery
    • Managing certain endocrine disorders
    • Controlling pain and swelling in livestock and pets

    Why Choose Dexafort 50ml Injection?

    Benefits of Dexafort

    • Rapid onset of action
    • Long-lasting effects
    • Versatility in treating multiple conditions
    • Widely trusted by veterinarians worldwide

    Why Buy Online in Kazakhstan?

    • Convenience and privacy
    • Access to competitive prices
    • Wide selection of trusted vendors
    • Availability of genuine products

    Where to Find Dexafort 50ml Injection for Sale Online in Kazakhstan

    Trusted Online Pharmacies and Veterinary Suppliers

    When purchasing Dexafort online, it's crucial to ensure you're buying from reputable sources to avoid counterfeit products. Look for verified vendors that:

    • Provide clear product descriptions
    • Have positive customer reviews
    • Offer secure payment options
    • Provide proper certification and licensing
    • ExampleVet.kz — A trusted veterinary supplier
    • KazPetPharma.kz — Known for genuine veterinary medicines
    • International platforms that ship to Kazakhstan (verify legality and authenticity)

    Regulatory Aspects

    • Ensure the product complies with Kazakhstan's veterinary medicine regulations
    • Use only licensed products prescribed by a licensed veterinarian
    • Be aware of import restrictions and customs procedures

    Safety Tips for Buyers

    • Avoid extremely low prices that may indicate counterfeit products
    • Verify seller credentials and reviews
    • Request certificates of authenticity
    • Do not share personal or payment information insecurely

    How to Use Dexafort 50ml Injection Safely

    Dosage and Administration

    Buy Dexafort Injection Online Kazakhstan. Always follow the veterinarian’s instructions. Typical dosages vary based on animal species, weight, and condition.

    Potential Side Effects

    • Increased appetite
    • Fluid retention
    • Suppression of natural cortisol production
    • Gastrointestinal disturbances

    Precautions

    • Not suitable for animals with systemic infections
    • Use with caution in pregnant or lactating animals
    • Monitor for adverse effects during treatment

    Cost and Pricing in Kazakhstan

    Pricing can vary depending on the supplier, quantity, and authenticity. Generally, a 50ml bottle of Dexafort may range from X to Y Tenge.

    Factors Affecting Price

    • Brand reputation
    • Source country
    • Bulk purchase discounts
    • Shipping and handling fees

    How to Identify Genuine Dexafort Products

    Packaging and Labeling

    • Clear labeling with manufacturer details
    • Proper batch number and expiry date
    • Sealed tamper-proof packaging

    Seller Credibility

    • Verified licenses
    • Customer feedback
    • Transparent return policies

    FAQs About Dexafort 50ml Injection in Kazakhstan

    Q1: Is Dexafort safe for all animals?
    A: No. It should only be used under veterinary supervision, considering species-specific responses and health conditions.

    Q2: Can I buy Dexafort online without a prescription?
    A: It’s recommended to have a veterinarian’s prescription to ensure safe and appropriate use.

    Q3: How long does it take for Dexafort to work?
    A: Effects are typically seen within a few hours, but this varies with the condition and administration route.


    Final Thoughts: Making a Safe Purchase in Kazakhstan

    Buying Dexafort 50ml injection online in Kazakhstan can be convenient and cost-effective when done responsibly. Always prioritize safety by purchasing from reputable vendors, verifying authenticity, and consulting a veterinarian before use.


    Conclusion

    Whether you’re a veterinarian, livestock farmer, or pet owner, understanding the importance of safe sourcing and proper usage of Dexafort 50ml injection is vital. By following the guidelines outlined above, you can confidently find quality products online in Kazakhstan, ensuring the health and well-being of your animals.


    Disclaimer: This article Buy Dexafort Injection Online Kazakhstan is for informational purposes only. Always consult a licensed veterinarian before administering any medication.

    Thursday, July 3, 2025

    Primobolan 100 For Animal Use



    Primobolan 10ml

    In the equine industry, performance enhancement and recovery are critical topics that often evoke both curiosity and controversy. Among various anabolic substances, Primobolan (methenolone acetate or enanthate) has gained attention for its purported benefits in horses. This article provides an in-depth analysis of Primobolan 10ml, covering its uses, benefits, potential risks, legal considerations, and best practices for administration.

     

    What is Primobolan?

    Primobolan is an anabolic steroid originally developed for medical purposes, such as treating muscle wasting diseases. Its popularity in the athletic community stems from its reputation for being a mild anabolic agent with fewer androgenic effects compared to other steroids.

     

    Forms of Primobolan

    • Primobolan Acetate: Short-acting injectable form.
    • Primobolan Enanthate: Longer-lasting injectable form, often used in veterinary applications.

     

    Primobolan 10ml for Horses: Overview

    The Primobolan 10ml formulation refers to a 10-milliliter vial of the steroid, typically administered via injection. In equine medicine, it is sometimes used to promote muscle growth, improve performance, and aid in recovery. Acth Gel

    Composition

    Molecule : Methenolone Enanthate

    Concentration : 100mg/ml

    Benzyl Alcohol

    Benzyl Benzoin

    USP Grade Camer Oil

     

    Why 10ml?

    The 10ml size offers a practical dosage volume for veterinary use, allowing for precise dosing over multiple administrations. Mepivicaine 100ml

     

    Uses of Primobolan in Horses

    1. Performance Enhancement

    Some trainers and veterinarians consider Primobolan for improving muscle mass and stamina in performance horses, such as racehorses or show jumpers.

    2. Recovery and Muscle Preservation

    Primobolan may help in recovery from injury by promoting muscle maintenance during periods of restricted activity.

    3. Therapeutic Applications

    Though less common, Primobolan can be used in specific medical cases requiring anabolic support.

    Note: The use of anabolic steroids in horses is strictly regulated in many countries. Always consult with a licensed veterinarian before considering such treatments.

     

    Benefits of Primobolan 10ml for Horses

    • Anabolic Effects: Promotes lean muscle development.
    • Low Androgenic Activity: Reduced risk of side effects like aggression or hair loss.
    • Long Half-Life: Especially if using the enanthate form, allowing for less frequent injections.
    • Potential for Improved Performance: Increased stamina and strength.
    • Lean Muscle Mass Growth 

    • Increase Stamina

    • Increase Fat Loss

    • Boosts Immunity

    • Enhance Strength 

    • Performance Enhancement

    • Prevent Muscle Wasting

    • Protein Synthesis

     

    Potential Risks and Side Effects

    While Primobolan is considered milder than other steroids, it still carries risks, especially when misused.

     

    Common Side Effects

    • Hormonal imbalances
    • Suppressed natural testosterone production
    • Changes in behavior
    • Injection site reactions

     

    Serious Risks

    • Liver toxicity (less common with injectable forms)
    • Cardiovascular issues
    • Reproductive disturbances

     

    Legal and Ethical Considerations

    • Doping Regulations: Many equine sports organizations prohibit anabolic steroids.
    • Legal Status: The legality of Primobolan varies by country; unauthorized use can lead to penalties.

     

    Proper Administration and Dosage

    The recommended dosage for beginners is 100mg per week and professional athletes are recommended dosage between 200 to 400mg per week.

    The ideal dosage depends upon the tolerance levels of each user and their blood work. Despite that, it is advised to start with a low dose and gradually increase it after every week.

    Female users are advised to take 50 to 100mg per week, however, results can still be achieved under 25 to 75mg dose per day.

    Veterinary Guidance

    Always administer Primobolan under the supervision of a licensed veterinarian familiar with equine pharmacology.

    Typical Dosage

    • Dosages vary depending on the horse's size, health, and purpose.
    • Common dosages range from 1 to 2 ml per administration, with frequency determined by the vet.

    Injection Technique

    • Administer intramuscularly, preferably in the neck or hindquarters.
    • Use sterile equipment to prevent infections.
    • Follow proper injection protocols.

    Monitoring

    • Regular health checks
    • Blood tests to monitor hormone levels and organ functions
    • Observation for adverse reactions

     

    Legal and Ethical Aspects

    Regulations in Different Countries

    • The use of anabolic steroids like Primobolan is heavily regulated.
    • Many organizations ban performance-enhancing drugs in competition.

    Ethical Considerations

    • Fair play in sports
    • Welfare of the horse
    • Long-term health implications

     

    Alternatives to Primobolan for Horses

    • Natural Training Methods: Proper diet and conditioning.
    • Other Veterinary-approved Supplements: Creatine, amino acids, and electrolytes.
    • Legal Performance Enhancers: As approved by regulatory bodies.

     

    Conclusion

    Primobolan 10ml for Horses represents a powerful but controversial option for enhancing performance and recovery in equine athletes. Its mild anabolic profile makes it attractive, but potential side effects, legal issues, and ethical concerns necessitate cautious use under professional guidance.

     

    Presentation

    10ml vial

     

    Final Recommendations

    • Always consult with a qualified veterinarian before using Primobolan injection.
    • Be aware of local laws and regulations regarding anabolic steroid use in horses.
    • Prioritize the health and well-being of the horse over performance gains.

    Wednesday, July 2, 2025

    Adequan For Horses

     



    Adequan Multi-Dose I.M. 50ml

    Adequan I.M. (100 mg/5 mL) for Equine is a prescription medication recommended for intramuscular use that is used in the treatment of arthritis, degenerative joint disease (not caused by infections), or joint injury with associated lameness.

    Adequan I.M. restores synovial fluid, stimulates cartilage repair, and decreases inflammation and joint pain. Adequan I.M. is Polysulfated Glycosaminoglycan and should be injected intramuscularly.

     

    Benefits Of Adequan

    Adequan I.M. for Equine (polysulfated glycosaminoglycan) is the only FDA-approved treatment proven to relieve symptoms of non-infectious degenerative osteoarthritis, to stimulate cartilage repair and reverse the joint disease process.

    • Treats equine non-infectious degenerative joint disease (DJD)
    • Helps protect and renew joint mobility
    • Restores synovial joint lubrication
    • Repairs joint cartilage
    • Reduces inflammation
    • Works quickly after administration

     

    Composition

    There is no generic version of Adequan I.M.

    Adequan i.m. active Ingredients Polysulfated glycosaminoglycan (PSGAG)

    5ml 500 mg/5 ml
    50ml Multi-Dose 100 mg/ml

    The recommended dose is 5ml every 4 days. Use for 28 days.

     

    Key Features:

    FDA-Approved: The only polysulfated glycosaminoglycan approved for equine DJD

    Comprehensive Treatment: Reduces inflammation, restores joint lubrication, repairs cartilage, and reverses DJD

    Trusted for Decades: Over 30 years of proven effectiveness in the equine community

    No Generic Equivalent: Unique formulation for specialized treatment of joint dysfunction

     

    Why Choose Adequan i.m.?

    No Generic Available: Ensures you're getting the specialized, proven formula

    Long-Standing Trust: A staple in equine joint health for decades

    Holistic Approach: Goes beyond symptom relief to promote overall joint health

    For optimal joint health and performance in horses, choose Adequan i.m. Equine. Invest in a treatment that's proven, trusted, and designed to enhance your horse's quality of life by addressing the root causes of degenerative joint disease in horses.

    Federal law restricts this drug to use by or on the order of a licensed veterinarian. Do not mix with other drugs or solutions. Do not give your horse Adequan I.M. if they are pregnant or lactating. Consult your veterinarian before use if your horse has liver or kidney disease, blood clotting or coagulation disorders. Keep out of reach of pets or children. Do not use in horses intended for human consumption. Not for use in humans.

    If an allergic reaction occurs after treating your horse with Adequan, stop treatment and seek emergency veterinary help.

     

    Packaging

    Single-Dose 500 mg/5ml $50

    Single-Dose 500 mg/5ml x 7ct multipack $332

    Multi-Dose 100 mg/50ml

    Multi-Dose 5000 mg/50ml $450

     

    TIMEFAST  INJECTABLE

    FENTANYL LIQUID

    Estrumate Cloprostenol Injection for Cattle

     


    In modern cattle management, reproductive health is paramount for ensuring optimal productivity, profitability, and animal welfare. Among the various pharmaceutical interventions available, Estrumate (cloprostenol injection) has gained widespread recognition among veterinarians, farmers, and livestock producers. This drug plays a vital role in managing estrus, facilitating reproductive protocols, and controlling certain reproductive disorders in cattle.

    This comprehensive guide aims to provide an in-depth understanding of Estrumate (cloprostenol injection for cattle) — its mechanism of action, indications, dosage, benefits, potential side effects, and best practices for use. Whether you are a veterinarian, cattle farmer, or livestock enthusiast, this article will serve as a valuable resource to optimize reproductive management using Estrumate.


    What Is Estrumate (Cloprostenol Injection)?

    Estrumate is a trade name for a synthetic prostaglandin F2α (PGF2α) analog known as cloprostenol. It is a potent luteolytic agent used primarily in cattle to induce estrus, synchronize breeding programs, and manage reproductive disorders.

    Key Features of Estrumate (Cloprostenol)

    • Synthetic prostaglandin analog designed to mimic natural prostaglandin F2α.
    • Rapid onset of action with predictable effects.
    • Effective in cattle for controlling the estrous cycle.
    • Administered via intramuscular injection for ease of use.

    How Does Cloprostenol Work?

    Understanding the mechanism of action is crucial for effective utilization.

    The Reproductive Hormone Cycle in Cattle

    In cattle, the estrous cycle is regulated by hormonal signals involving:

    • Luteinizing hormone (LH)
    • Follicle-stimulating hormone (FSH)
    • Progesterone
    • Estrogen

    The corpus luteum (CL) produces progesterone, which maintains pregnancy or suppresses estrus if the cow is not pregnant.

    Role of Prostaglandin F2α (PGF2α)

    Prostaglandin F2α causes luteolysis, the regression of the corpus luteum, leading to a decrease in progesterone levels. This hormonal change triggers the cow to enter estrus (heat), making her receptive to breeding.

    Cloprostenol's Action

    Cloprostenol, as a synthetic PGF2α analog, binds to prostaglandin receptors on luteal cells, inducing luteolysis rapidly. This results in:

    • Regression of the corpus luteum.
    • Decrease in progesterone.
    • Onset of estrus within a predictable timeframe.

    Note: Cloprostenol is more potent and longer-lasting than natural prostaglandins, which allows for more precise control of reproductive events.


    Indications for Using Estrumate (Cloprostenol Injection)

    Cloprostenol injections like Estrumate are primarily used in the following situations:

    1. Estrus Synchronization

    • To synchronize the estrous cycle of a group of cattle.
    • Facilitates timed artificial insemination (TAI).
    • Improves reproductive efficiency.

    2. Treatment of Reproductive Disorders

    • Persistent corpus luteum (PCO): To induce luteolysis and facilitate estrus.
    • Cystic ovarian follicles: To regress cysts and restore normal cycles.
    • Pyometra: In some cases, to help resolve uterine infections linked with persistent CL.

    3. Induction of Parturition

    In some cases, cloprostenol is used off-label to induce abortion or parturition, but this should only be done under veterinary supervision.


    Dosage and Administration

    For cattle, the typical dosage of Estrumate (cloprostenol):

    • 2 mL per 450 kg (approximately 1000 lbs) body weight.
    • This provides 250 micrograms of cloprostenol per dose.

    Administration Protocol

    • Intramuscular injection into the neck muscle.
    • For estrus synchronization, a common protocol involves administering the injection and observing for estrus signs within 48-72 hours.
    • In multi-dose protocols, injections may be repeated after 11 days to increase synchronization efficiency.

    Handling and Storage

    • Store in a cool, dry place away from direct sunlight.
    • Keep out of reach of children and unauthorized personnel.
    • Use before the expiration date printed on the packaging.

    Reproductive Synchronization Protocols Using Estrumate

    Several protocols utilize Estrumate to synchronize estrus in cattle:

    1. Single Dose Protocol

    • Inject 2 mL of Estrumate IM.
    • Observe animals for estrus signs within 48-72 hours.
    • Breed or schedule artificial insemination accordingly.

    2. Double Dose Protocol

    • Administer 2 mL of Estrumate IM.
    • Repeat after 11 days.
    • Estrus usually occurs within 48-72 hours after the second injection.
    • Ideal for herds with variable cyclicity.

    3. Combined Protocols with Other Hormones

    Sometimes combined with progestogens or gonadotropins for enhanced synchronization, especially in advanced reproductive management programs.


    Benefits of Using Estrumate (Cloprostenol)

    Implementing Estrumate in your reproductive management offers several advantages:

    1. Improved Reproductive Efficiency

    • Reduces the interval between calving and conception.
    • Enhances conception rates through precise timing of insemination.

    2. Cost-Effective and Easy to Use

    • Single intramuscular injection with predictable effects.
    • Suitable for large herds.

    3. Facilitates Artificial Insemination Programs

    • Enables timed insemination without the need for estrus detection.
    • Increases genetic progress by enabling planned breeding.

    4. Treats Reproductive Disorders

    • Helps in managing cystic ovaries or persistent corpora lutea effectively.

    Potential Side Effects and Precautions

    While Estrumate (cloprostenol) is generally safe when used correctly, awareness of potential side effects is essential:

    Common Side Effects

    • Mild transient discomfort at the injection site.
    • Short-lived changes in behavior, such as restlessness or irritation.
    • Slight abdominal cramping.

    Rare Side Effects

    • Excessive uterine contractions.
    • Allergic reactions (rare).

    Precautions

    • Pregnancy: Avoid administering during confirmed pregnancy, as it can induce abortion.
    • Breeding: Do not breed the animal within 48 hours of injection.
    • Handling: Use protective equipment to prevent accidental self-injection.
    • Residue Safety: Observe withdrawal periods before slaughter to ensure drug residues are cleared.

    Best Practices for Using Estrumate in Cattle

    To maximize efficacy and safety:

    • Follow the recommended dosage and protocol.
    • Timing is crucial: administer injections at the correct stage of the estrous cycle.
    • Observe animals closely for estrus signs post-treatment.
    • Record all treatments for herd management and traceability.
    • Consult a veterinarian for complex cases or if unexpected reactions occur.
    • Combine with proper herd management practices, including nutrition and hygiene.

    Comparing Estrumate to Other Prostaglandin Products

    Several prostaglandin F2α analogs are available in the market, including:

    Product NameActive IngredientDuration of ActionNotable Features
    EstrumateCloprostenolLonger-lastingHigh potency, reliable results
    LutalyseDinoprost tromethamineShorterWidely used, versatile
    PGF2α (generic)Prostaglandin F2αVariableCost-effective, generic options

    Cloprostenol (Estrumate) is often preferred for its longer half-life and predictable response, especially in protocols requiring precise timing.


    • Use only as prescribed by a licensed veterinarian.
    • Ensure compliance with local drug residue regulations.
    • Keep detailed records of treatments for traceability.
    • Be aware of withdrawal periods before slaughter. Lipotalon

    Future Perspectives and Innovations

    Research continues to improve prostaglandin analogs' efficacy and safety profiles. Innovations include:

    • Extended-release formulations for prolonged effects.
    • Combination products for synchronized protocols.
    • Advances in precision reproductive management leveraging data analytics and AI.

    Conclusion

    Estrumate (cloprostenol injection for cattle) remains a cornerstone in modern reproductive management, offering predictable, effective, and versatile solutions for estrus synchronization and treatment of reproductive disorders. When used correctly, it can significantly enhance herd fertility, improve management efficiency, and contribute to the overall productivity of cattle operations.

    Always remember:

    • Follow recommended protocols.
    • Consult with veterinary professionals.
    • Maintain diligent herd health and management practices. bST

    By integrating Estrumate into your reproductive strategies responsibly, you can achieve better herd performance and economic returns.


    References


    For more detailed advice tailored to your herd, always consult your veterinarian.