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– The combination between of phenylbutazone and dexamethasone enhance animal’s resistance during training and exercise or working with high pressure. Naquadem naquasone 20 ml
METHOD OF ADMINISTRATION: Apply 5 ml for 5 days – IM (suspend 7 days before the race).
Best Medication use in horse racing has become a hot topic across the country. Uniform standards have been established by the Racing Medication and Testing Consortium (RMTC) for the United States. However, not all states are following these guidelines.1,2 The National Uniform Medication Program consists of medication rules, penalties, and testing guidelines. Additionally, the policy contains the Controlled Therapeutic Substances list, a policy limiting administration of furosemide to third-party veterinarians, a multiple medication violation penalty system, and a laboratory quality assurance program.1
Best Medication Use In Horse Racing : Approved Controlled Therapeutic Medications
The RMTC has established a list of 30 approved controlled therapeutic medications that have use for treating medical conditions in horses, along with withdrawal guidelines to avoid positive tests during races.1 For example, omeprazole may be used to treat or prevent ulcers in horses, and it is recommended to be stopped approximately 24 hours prior to racing.1 It is important to note that administration of more than 1 medication can affect the time for the drug to leave the system, which can cause a positive drug test. Twenty-six states have currently adopted the Controlled Therapeutic Substances List.1 The following medication classes are generally banned from horse racing: anabolic steroids, peptide hormones and growth factors, beta-2 agonists, hormone and metabolic modulators, and certain diuretics.1
The Furosemide Controversy
One controversial medication issue is the use of furosemide (Lasix, Validus) on race day. It is typically administered 4 hours prior to a race to prevent exercise-induced pulmonary hemorrhage (EIPH), which causes bleeding in the lungs and from the nose of horses during strenuous exercise. Since furosemide reduces plasma volume, it is thought to lower blood pressure in the lungs to prevent bleeding. However, there is mixed evidence regarding the efficacy of furosemide for EIPH. In fact, a recent study demonstrated that administration of furosemide both 4 and 24 hours prior to high-speed training did not prevent EIPH. The study did show that furosemide reduced the severity of EIPH in those horses affected with this condition.
The American College of Veterinary Internal Medicine issued a consensus statement that EIPH is considered a disease, and offers a weak recommendation for the use of furosemide for the management of racehorses with EIPH.3 Many questions have been raised as to whether furosemide can be considered performance enhancing, since with fluid loss horses may race faster. Also, diuretics can potentially mask the use of banned drugs. Europe and Australia have banned the use of furosemide on race day due to these concerns.6 There are actually 28 states that allow the use of furosemide on race day, including Kentucky, which is home to one of the most well-known races, the Kentucky Derby, that occurs annually in May.1 Interestingly, California allows conjugated estrogens and furosemide on race day. Conjugated estrogens have not shown a therapeutic benefit for EIPH.
There is currently a federal bill, known as the Horseracing Integrity Act, supported by 64 trainers, that was introduced last year which would establish an agency to monitor medication policy in horse racing and would ban race day furosemide.7 Although there is support for this bill, some opposition remains among the racing industry. The program would consist of the following measures: anti-doping and medication control rules; lists of permitted and prohibited substances; prohibition on the administration of any medication within 24 hours of the race start; and testing and laboratory standards. Burn Horse Durvet
The Bottom Line and Pharmacist Involvement
Based on the available evidence, there may be a place for furosemide in horses with EIPH, but it should not be used in healthy horses for prevention. Many questions regarding the longterm use of furosemide in horses remain to be answered, such as whether it affects the breeding process. There should be federal laws in place for restrictions on medications used in horse racing. The Horseracing Integrity Act could be an important piece of legislation that may assist with establishing federal regulatory standards. Veterinary pharmacists could play an important role in providing drug information education to the horse racing industry on the use of race day medications. Read More
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Dexalone Solution, Dexamethasone 2 mg/ml solution injectable for injection for horses, cattle, goats and pigs for the treatment of inflammatory osteoarticular conditions.
Indications:
In horses, cattle, goats and pigs: treatment of inflammatory, allergic or shock conditions. • In horses: treatment of inflammatory osteoarticular conditions. • In cattle and goats: – Treatment of primary ketosis (acetonemia, pregnancy toxemia); • In cattle – Induction of parturition. White Lightning 100ml
Buy dexaphenylbutazone 100ml online is a member of glucocorticoid family and like other drugs in this group it has a pharmacologic effect in all cells on the body. From different effects immunosuppressive (partially or completely suppressing the immune response of an individual) and anti inflammatory actions have been more evaluated and is indicated in these medical conditions. Glucocorticoid drugs inhibit the effects of lytic enzymes (relating to or causing lysis in tissues and cells as a destruction effect), which are released in inflammations and severe stress conditions. Also the phagocytosis effect by macrophages will be decreased.Contact Us
dexaphenylbutazoneis another active ingredient in this product belongs to NSAIDs group of drugs and its mechanism of action is different from dexamethasone. Like other NSAID drugs phenylbutazone inhibits the prostaglandin’s inflammatory effects that produce pain and inflammation in the body. By this mechanism other effects of prostaglandins like fever is also blocked. Besides phenylbutazone interfere in early stage of inflammation and reduce the permeability of vascular beds and prevent from edema and diapedesis (the passage of blood cells through the intact walls of the capillaries, typically accompanying inflammation).
By the combination of two active ingredients with different mechanism of action anti-inflammatory and pain relief of this product is predominant.
Indications of use
Anti inflammatory, antipyretic and analgesic. Musculoskeletal inflammations like arthritis, osteoarthritis, laminitis and tendonitis in horses.
Dosage and route of administration for dexaphenylbutazone
Horses: 20 ml/day by slow IV injection that can be repeated depending on the severity of the conditions.
Foals: Slow IV or deep IM: 6 – 10 ml to be repeated 24 -48 hours later depending on the severity of the case.
Contraindications for dexaphenylbutazone
In case of vascular brittle and congestion the recommended dose must be decreased and the second dose must not be applied.
Also in the animals with heart, liver or kidney problems or in the end term of pregnancy this product is contraindicated.
After the use of first dose the remaining medicine can be used in 28 days.
Protect the vials in boxes and out of the direct sun light.
Do not use concomitantly with NSAIDs and other corticosteroid drugs. IV injection must be done slowly.
Do not use more than recommended dosage.
Do not sale without veterinary prescription.
Keep out of reach of children.
Storage conditions
Protect in 15 – 25° C and direct sun light.
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Etherlite will be airdropping a total of 2.1 Billion ETL coins to ETH holders. Hold your ETH in a private wallet at the time of snapshot to be eligible to claim the airdrop. The snapshot will be taken on May 1st, 2021 Yodi at Ethereum block no 12345678. Eligible holders will be able to claim ETL starting from July 1st, 2021.Step-by-Step Guide:
Hold your ETH in a private wallet during the snapshot.
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A total of 2.1 Billion ETL coins will be airdropped in which all eligible holders will be able to claim between 10 – 15 ETL per 1 ETH.
For more information regarding the airdrop, see this Medium article.
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